Serum α-synuclein was found to be increased in children with obesity and type 1 diabetes (T1D), which was linked to the impairment of executive function in these children. A study published in the ...

Much of the research into α-synuclein, the major component of Lewy bodies in Parkinson’s and other neurodegenerative diseases, focuses on its role in synaptic vesicles and membranes. But could other ...

Yunseon Yang, Jae-Jin Song, Yu Ree Choi, Seong-hoon Kim, Min-Jong Seoka, Noviana Wulansari, Wahyu Handoko Wibowo Darsono, Oh-Chan Kwon, Mi-Yoon Chang, Sang Myun Park, Sang-Hun Lee Proceedings of the ...

Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...

Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only a tiny fraction ...

α-synuclein (α-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphorylation of α-syn at ...

The exact molecular mechanism via which α-synuclein, the main protein involved in Parkinson’s pathogenesis, aggregates is yet to be understood completely. In a recently published study, a team of ...

A new study has developed an assay that can identify incorrectly folded α-synuclein, a biomarker of synucleinopathies, in patient serum. Synucleinopathies are neurodegenerative diseases, such as ...

Heather Rice can recall a moment early in her career that helped shape how she thinks about Alzheimer’s disease. It happened when she was a zoology major at the University of Oklahoma in 2007, after ...