Nature

Cell-to-cell expression variability followed by signal reinforcement progressively segregates early mouse lineages

It is now recognized that extensive expression heterogeneities among cells precede the emergence of lineages in the early mammalian embryo. To establish a map of pluripotent epiblast (EPI) versus ...
Nature

Cells change their sensitivity to an EGF morphogen gradient to control EGF-induced gene expression

Figure 1: Measuring Notch ligand expression dynamics during vulva induction. To address these questions we systematically quantify Notch ligand expression during vulva induction. We find that Notch ...