Proceedings of the National Academy of Sciences of the United States of America, Vol. 117, No. 38 (September 22, 2020), pp. 23571-23580 (10 pages) DNA replication requires the sliding clamp, a ...

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem - a failsafe that is critical to maintaining health and staving off ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

Though scientists have learned much about DNA damage and repair over the past 50 years, important outstanding questions remain. One particularly bedeviling puzzle is how a repair protein called the ...

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem -- a failsafe that is critical to maintaining health and staving off ...

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism. What’s not captured by this analogy is the fact that our DNA ...

During the process of bacterial DNA replication, DNA Polymerase, which catalyze the synthesis of DNA, plays an indispensable role. In order to keep DNA Polymerase III sliding along, a protein complex ...

The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...

The results of this collaborative project overturn some conventional wisdom about how the DNA repair process works. DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts ...