The inefficiency induced by between-cluster variation in cluster randomized (CR) trials can be reduced by implementing a crossover (CO) design. In a simple CO trial, each subject receives each ...

A cluster randomised trial (CRT) is a randomised controlled trial in which pre-existing groups, called clusters, of individuals are randomly allocated to treatment arms. For example, clusters may be ...

Objectives: Cluster randomised trials, in which groups of individuals are randomised, are increasingly being used in the health field. Adopting a clustered approach has implications for the design of ...

A targeted computerized alert at the time of physician order entry reduced the use of D-dimer testing among patients 65 years and older. A single-crossover cluster randomized trial of computerized ...

Background: The Canadian CT Head Rule was developed to allow physicians to be more selective when ordering computed tomography (CT) imaging for patients with minor head injury. We sought to evaluate ...

Adjuvant Nivolumab in High-Risk Muscle-Invasive Urothelial Carcinoma: Expanded Efficacy From CheckMate 274 Sixteen towns in Sihui and Zhongshan cities, China, were selected; eight were randomly ...

There are approximately 4 million neonatal deaths and half a million maternal deaths worldwide each year. There is limited evidence from clinical trials to guide the development of effective maternity ...

ORLANDO, FL—Giving patients vouchers to cover co-payments for a P2Y12 inhibitor post-MI leads to more patients taking the pricier but more potent ticagrelor instead of clopidogrel, new data from the ...