It's Week 17 and the fantasy playoffs championships in most leagues, so choosing the right D/ST option could be the deciding factor in your matchups. Set your D/ST lineups with our fantasy football playoffs defense (DST) rankings for Week 17.

The Buffalo Bills (11-4) take a four-game winning streak into their contest with the Philadelphia Eagles on Sunday, December 28, 2025 at Highmark Stadium.

After an eventful first half, neither team scored any points in the third quarter.