Researchers analyzed the thermodynamics of doxepin binding to the histamine H1 receptor. The findings highlight the ...
There’s no doubt that large language models and generative AI tools have taken the world by storm. Their ability to create, ...
News Medical on MSN
Thermodynamic insights into histamine H1 receptor ligand binding
G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...
Understanding the thermodynamic basis of ligand recognition by G-protein-coupled receptors (GPCRs), especially in terms of ...
Pharmaceutical Technology on MSN
RNA-targeting small molecules: A new frontier of drug discovery
With big pharma signalling interest in novel RNA-targeted approaches, the term “druggable” is being redefined as technology ...
GUEST COMMENTARY—For millions of patients, the slow pace of drug discovery means years – sometimes decades – without effective treatments. Many diseases remain untreatable, not because they are rare ...
Promega Corporation has introduced a new platform designed to help drug discovery scientists study some of the most challenging protein targets in living cells, enabling earlier and more reliable ...
Thought LeadersEdoardo FabiniPrincipal Scientist Evotec U.K. G-protein-coupled receptors (GPCRs) play a pivotal role in cellular signaling and have long been a major focus in drug discovery. These ...
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