JSTOR Daily

Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Trims MHC Class I-Presented Peptides in vivo and Plays an Important Role in Immunodominance

CD8⁺ T cells respond to short peptides bound to MHC class I molecules. Although most antigenic proteins contain many sequences that could bind to MHC class I, few of these peptides actually stimulate ...
JSTOR Daily

Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins

Silvia Hüttner, Christiane Veit, Ulrike Vavra, Jennifer Schoberer, Eva Liebminger, Daniel Maresch, Josephine Grass, Friedrich Altmann, Lukas Mach and Richard Strasser To ensure that aberrantly folded ...
Business Wire

Quentis Therapeutics Debuts with $48 Million Series A Financing to Advance First-in-Class Immunotherapies Targeting Endoplasmic Reticulum Stress Response Pathways

NEW YORK--(BUSINESS WIRE)--Quentis Therapeutics Inc., a biotechnology company pursuing next-generation immuno-oncology research and drug development, debuted today with the completion of a $48 million ...
Science Daily

Endoplasmic reticulum stress plays significant role in type 2 diabetes

The endoplasmic reticulum plays a more important role in type 2 diabetes and its complications than previously believed, new research suggests. To make their discovery, scientists identified several ...