The establishment and maintenance of neuronal identity are critically dependent on a finely tuned interplay between transcription factors and the epigenetic landscape. Central to this network is the ...

The team of Professor Christof Niehrs at the Institute of Molecular Biology (IMB) in Mainz, Germany, has discovered that a DNA modification called 5-formylcytosine (5fC) functions as an activating ...

Cellular maturation involves transcriptional, metabolic, and physiological changes that drive cell function. In human neurons, this process takes longer than in most other cell types, lasting almost ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

Images of the nucleus of an excitatory neuron of a control mouse and a mouse in which KDM1A and KDM5C have been simultaneously deleted in the adult brain. The DAPI signal (DNA) is shown in gray, and ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

When a new memory forms the brain undergoes physical and functional changes known collectively as a “memory trace.” This memory trace represents the specific patterns of neuronal activity and ...

According to the 2016 Annual Review of Neuroscience, “the brain has emerged as a main target of genomic imprinting, generating great interest in how this epigenetic regulation provides stable ...