A growing body of research has identified a hidden immune defect, not written in DNA, that helps explain why certain people develop life-threatening COVID-19 while others barely notice the infection.

Shi’s study, "Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling," was recently published in Nature Communications. “Concerted efforts ...

The regulation of type I interferon (IFN-1) signaling is crucial for fine-tuning the innate immune response to combat pathogens, fight cancer and prevent autoimmune diseases. Disrupted IFN-1 signaling ...

Interferon signatures may be a candidate biomarker for early identification of response to lupus nephritis induction treatment. Persistent type I interferon-driven transcriptional activity in ...

By Dr. Priyom Bose, Ph.D. A new study uncovers interferon gamma as both a powerful blood-based signal of Alzheimer’s disease ( AD ) and a potential mechanistic bridge between genetic risk and damaging ...

Mount Sinai researchers have identified a cellular mechanism linking infections from influenza A viruses (IAVs) to cardiovascular disease, providing critical insights on how influenza can damage the ...

A unique quality of the immune system is that it can generate a ‘memory’ response. This is generally referred to as ‘immune ...

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...