Innate immunity constitutes the body’s first line of defence against invading pathogens. This ancient, evolutionarily conserved system is activated within minutes of encountering foreign agents, ...

The complement component C5a and its receptors, C5aR1 and C5aR2, are central to the orchestration of innate immunity. C5a is a potent anaphylatoxin generated during complement activation, acting as a ...

Filoviruses are negative-sense and single-stranded ribonucleic acid (RNA) viruses. The most well-known human-infecting filoviruses are marburgviruses and ebolaviruses. Infection can result in ...

The liver is the largest organ in the human body. It is suggested that hepatokines secreted from the liver play important roles in hepatocytes as well as immunocompetent cells in other organs. In this ...

In several disease conditions, including infections and cancers, innate immune activation and nutrient scarcity occur ...

Saleela M. Ruwanpura, Louise McLeod, Lovisa F. Dousha, Huei J. Seow, Alison C. West, Alice J. West, Teresa Weng, Mohammad Alanazi, Martin MacDonald, Paul T. King ...

This is the crystal structure of human STING, bond with a synthetic a drug currently in clinical trials for cancer. The same drug stops SARS-Cov-2 from infecting and killing susceptible animals, and I ...

When the worldwide death toll from Covid-19 surpassed five million two weeks ago, it served as a grim reminder that more than lockdowns and vaccines will be needed to end the pandemic. A new study, ...

Innate immune responses to cell damage-associated molecular patterns induce a controlled degree of inflammation, ideally avoiding the promotion of intense unwanted inflammatory adverse events. When ...

Fructose can dramatically increase the sensitivity of immune cells to bacterial toxins, researchers at the University of ...

Currently, animal-borne viral diseases seriously threaten the development of the world's breeding industry, especially in ...