Angiogenesis and lymphangiogenesis have important roles in cancer progression: angiogenesis, the growth of new blood vessels, promotes tumour growth and tumour metastasis, and lymphangiogenesis, the ...

This year’s Lasker Basic Medical Research Award recognizes the contributions of Drs. Richard Hynes, Erkki Ruoslahti, and Timothy Springer for their discovery and characterization of integrins, a major ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

Eleven years ago, scientists discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea. The next step was to find the cellular receptor on ...

The Fagerholm group studies the role of leukocyte integrins in various immune reactions. We are interested in the in vivo roles and regulation of leukocyte beta2-integrins in a healthy and ...

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated the role of integrin signaling in vascular dysfunction associated with severe acute respiratory syndrome coronavirus ...

Phagocytosis by monocytes or neutrophils can be enhanced by interaction with several proteins or synthetic peptides containing the Arg-Gly-Asp sequence. Recently we showed that an mAb, B6H12, ...

This is a preview. Log in through your library . Abstract Aortic endothelial cells adhere to the core protein of murine perlecan, a heparan sulfate proteoglycan present in endothelial basement ...

Newly unveiled startup Morphic Therapeutic hopes that it’s solved some of the technical challenges that have hindered integrin-targeting therapeutics. It’s got more insight into their mechanism of ...

Eleven years ago, Dr. Mary Estes of Baylor College of Medicine and her colleagues discovered the first viral enterotoxin, rotavirus NSP4, a toxic protein that affects the intestines, causing diarrhea.