Tau aggregation begins not in the cortex, but in the brainstem. Does tangle deposition in the locus coeruleus, which often starts in a person’s 30s, presage Alzheimer’s disease? In the September 22 ...

Andrew Luskin conducted research on the brain's peri-locus coeruleus neurons while he was a UW Medicine neuroscience Ph.D. student. A small cluster of cells deep within our brains, called the locus ...

A new study in Biological Psychiatry has linked signs of heightened arousal and reactivity -- a core symptom of posttraumatic stress disorder (PTSD) -- to overactivity of the locus coeruleus (LC), a ...

A restful night alternates in cycles between non-rapid eye movement (NREM) and rapid eye movement (REM) sleep states. The study from UNIL shows that a brain region called the "locus coeruleus" (in ...

We found that the locus coeruleus may provide the critical 'start' signal to the hippocampus, as if saying, 'Hey, we're in a new event now,'" said Davachi. "Prior work had shown that bursts of locus ...

Deep within the brainstem is a structure no bigger than a grain of rice, the locus coeruleus. The LC is often referred to as the “blue spot” because of a distinct blue pigment produced from its inner ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 18 (May 3, 2022), pp. 1-12 (12 pages) The noradrenergic locus coeruleus (LC) is a controller of brain and ...