This figure depicts the complex regulatory network that maintains cellular cholesterol homeostasis. Metabolic and hormonal signals, including oxysterols, IGF-1, and FGF19, activate kinase cascades ...

A study led by scientists at Duke-NUS Medical School has identified the pivotal but previously unknown role of an enzyme, called FAXDC2, that is suppressed in cancers with hyperactive Wnt signalling.

How cholesterol that enters the cell through NPC1L1 reaches the endoplasmic reticulum for esterification and regulation of cholesterol synthesis has been a longstanding mystery. We solve that mystery ...

Plasma LDL-C concentrations can potentially be lowered either by inhibiting the synthesis of cholesterol by the tissues and/or driving the excretion of cholesterol from the body. Although blocking ...

Researchers have identified a previously unknown step in the process by which dietary cholesterol is absorbed from the intestine into the bloodstream. The newfound pathway provides a potential new ...

Scientists at UCLA described a previously unknown step in the complex process by which dietary cholesterol is processed in the intestines before being released into the bloodstream. The finding might ...

A concise, high-yield guide to cholesterol-lowering therapies—statins, Zetia, PCSK9 inhibitors, bempedoic acid, berberine, and key dietary tweaks—plus insights on benefits, risks, and mechanisms.

Mutations in LXRα lead to liver cholesterol buildup, hepatitis, and fibrosis in individuals on a Western diet, highlighting the receptor's role in maintaining liver health. Study: Damaging mutations ...