Microbe might spark first stages of ulcerative colitis: new study

A new study reveals how gut bacteria may initiate ulcerative colitis by weakening immune defenses before inflammation occurs.
BioWorld

PDE4 prodrug exhibits colon-selective bioactivation in colitis models

Phosphodiesterase-4 (PDE4) is an intracellular pro-inflammatory enzyme that is considered a therapeutic target in inflammatory disorders such as psoriasis, asthma or ulcerative colitis (UC), among ...
BioWorld

ICB treatment induces colitis-related indicators in DSS drinking mouse model

Researchers from Chinese Academy of Sciences detailed the creation of a new dextran sulfate sodium (DSS)-based mouse model of immune checkpoint blockade (ICB) therapy-associated colitis.
Business Wire

QPS Expands Offerings With Robust Pharmacology Disease Models, Including MASH, Ulcerative Colitis, Wound Healing, and Psoriasis

TAIPEI, Taiwan--(BUSINESS WIRE)--QPS, a leading global contract research organization (CRO) specializing in preclinical and clinical drug development services, is pleased to announce the expansion of ...
Nasdaq

Abivax Provides Update on Ulcerative Colitis (UC) Combination Therapy Program Strategy and Announces Early Preclinical Combination Data of Obefazimod and Etrasimod in ...

Abivax is actively conducting preclinical studies with multiple oral and injectable therapies and will report additional data in Q4 2024. Pre-clinical evaluation of obefazimod combined with etrasimod ...
The Scientist

Why Smoking Surprisingly Soothes Ulcerative Colitis Symptoms

“Smoking is, of course, bad. But for ulcerative colitis, somehow smoking helps to improve the disease states,” said Hiroshi Ohno, an intestinal immunologist at the Institute of Physical and Chemical ...