First-time use of AI for genetic circuit design demonstrated in a human cell line

There are hundreds of cell types in the human body, each with a specific role spelled out in their DNA. In theory, all it ...

Researchers expand human genome map to 2.37 million regulatory DNA elements

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the ...
Nature

DNA sequencing articles from across Nature Portfolio

DNA sequencing is any chemical, enzymatic or technological procedure for determining the linear order of nucleotide bases in DNA. Sanger sequencing by replicative synthesis in the presence of dideoxy ...
Nature

Double-strand DNA breaks articles from across Nature Portfolio

Sae2 phosphorylation by CDK and checkpoint kinases tunes MRX nuclease activity and Rad53 phosphorylation, allowing cells to couple DNA end clipping and checkpoint attenuation to safeguard genome ...