While the 49ers will be without left tackle Trent Williams for a fourth straight game on Thursday night, there's at least a ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

San Francisco 49ers cornerback Deommodore Lenoir is set to return for Sunday's game against the Chicago Bears after missing ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of ...

RB Christian McCaffrey looked to finally be taking off after his return from an Achilles injury but suffered a PCL injury ...

If there was ever a must-win scenario for the San Francisco 49ers, this week is it. The team has to get it done against the ...

More likely, the 49ers will end the season as the NFL’s most disappointing team. That’s where they are right now, and no one else is really close. They’re a victim of their own success, having gone to ...

San Fransisco 49ers running back Christian McCaffrey already missed the first eight games of the NFL season due to ...