RB Christian McCaffrey suffers potentially season-ending knee injury in loss to Bills, adding to team's struggles.

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The Bills and the San Francisco 49ers went head-to-head in freezing conditions Sunday, with Bills fans and staff digging out ...

Buffalo Bills fans embraced the snowy conditions at Highmark Stadium in Orchard Park, New York, on December 1, as their team ...

In a season that began with many questions and lowered expectations, it was apt watching Bills quarterback Josh Allen join ...

Lake-effect snow blanketed swaths of the U.S. as Thanksgiving travelers journeyed home this holiday weekend, with more snow ...

Snow continued to fall Monday around parts of the Great Lakes region, where storm-weary residents who have plowed and ...

It's Buffalo Bills vs San Francisco 49ers in Week 13 of the NFL season. Can Josh Allen and company outduel Christian McCaffery and Deebo Samuel?

Back-to-back blowout losses and another injury to star back Christian McCaffrey might just be the final blow to the dwindling ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

Parts of the Great Lakes region are seeing new snow and face the prospect of even more this week after U.S. travelers battled ...

Lake effect snow is slamming the Great Lakes, with seven states from Wisconsin to New York under snow alerts on Monday.