eLife3h
Circuit function is more robust to changes in synaptic than intrinsic conductances
This study provides valuable insights into the differential impact of intrinsic and synaptic conductances on circuit robustness, emphasizing intrinsic plasticity as a crucial but often overlooked ...
eLife5h
Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity
The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory ...
eLife5h
AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production
This work presents a valuable exploration of AI-assisted protein engineering, particularly in designing a VHH antibody with enhanced resistance and stability to extreme environments. However, the ...
eLife3d
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...
eLife4d
Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening
In this potentially valuable study, the authors employed in vivo experiments and theoretical modeling to study the growth dynamics of nuclear condensates. They observed that condensates can exhibit ...
eLife4d
Brain Activity: Unifying networks of a rhythm
Combining electrophysiological, anatomical and functional brain maps reveals networks of beta neural activity that align with dopamine uptake.
eLife4d
Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity
Major differences among the main spinal V1 inhibitory interneuron subgroups were revealed based on neurogenesis, circuit placement, and motoneuron targeting, and Foxp2-V1 interneurons were identified ...
eLife4d
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
This interesting study presents valuable information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations.
eLife5d
Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis
This valuable study reports the first characterization of the CG14545 gene in Drosophila melanogaster, which the authors name "Sakura." Acting during germline stem cell fate and differentiation, ...
eLife4d
Evaluating hippocampal replay without a ground truth
During rest and sleep, memory traces replay in the brain. The dialogue between brain regions during replay is thought to stabilize labile memory traces for long-term storage. However, because replay ...
eLife4d
Still waters run deep: Large scale genome rearrangements in the evolution of morphologically conservative Polyplacophora
This compelling study is a splendid advance in approximately doubling the number of sequenced chiton genomes, providing what appears to be among the best genome annotations for chiton genomes ...
eLife5d
Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells
Campus Chemical Instrument Center, Mass Spectrometry & Proteomics Facility, The Ohio State University, Columbus, USA ...