Nov 14, 2025 · Complete information for NFKB1 gene (Protein Coding), Nuclear Factor Kappa B Subunit 1, including: function, proteins, disorders, pathways, orthologs, and expression.

NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products.

NFKB1 or NFKB2 (164012) is bound to REL (164910), RELA (164014), or RELB (604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, 164008 or NFKBIB, …

NFKB1 plays an essential novel role for human NK cell maturation. Lipopolysaccharide treatment recruited Jmjd3 and NF-kappaB to the promoter region of target genes, suggesting Jmjd3 synergizes …

NF-κB proteins are Rel family transcription factors that function as homo- or heterodimers. Their transcriptional activation domain is present in RELA (p65), RELB and c-REL, but not in p50 (a …

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Oct 13, 2021 · NFKB1 encodes the p105 subunit of NF-ĸB which is processed to generate the NF-ĸB p50 subunit. NFKB1 is the most highly expressed transcription factor in macrophages, key cellular …

NF-κB was discovered by Ranjan Sen in the lab of Nobel laureate David Baltimore via its interaction with an 11-base pair sequence in the immunoglobulin light-chain enhancer in B cells. [14] Later work by …

Objective: To characterize the clinical and cellular phenotype as well as the management of patients with heterozygous NFKB1 mutations. Methods: In a worldwide collaborative effort, we evaluated 231 …

NFKB1 (KBF1, NF-kappaB, NF-kB1, NFkappaB, NFKB-p50, p105, p50) protein expression summary.