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Unlike the other key blood types, O negative is missing all highly reactive antigens – that’s why it’s called ‘O negative’. The letter ‘O’ indicates an absence of A and B antigens, while ‘negative’ indicates the absence of the Rh factor (RhD). Without these, there’s nothing to alert the recipient’s immune system. When O negative blood is transfused into a recipient, it can slip in undetected, and do all the good things blood does without triggering an immune response. That’s why O negative blood
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