mRNA vaccines for orthoflaviviruses mRNA technologies offer speed, scalability, and flexibility, making them ideal for multivalent and outbreak-responsive vaccine strategies. mRNA platforms have the potential to meet the urgent need for vaccines against orthoflaviviruses: pathogens responsible for widespread disease, and which impose a global health burden, but still lack broadly protective solutions. Rational antigen design innovations in mRNA vaccines for orthoflaviviruses – such as fusion loo